MR-Clust

Author

Eleanor Sanderson

Published

September 11, 2020

Resources

Code (Language: R) Website Paper (Pub Date: 2020-09-11)

Other URLS: none

Method Contact: Stephen Burgess ( sb452@medschl.cam.ac.uk)

Entry Contact: Eleanor Sanderson ( eleanor.sanderson@bristol.ac.uk)

Context

Analysis Type: UVMR MVMR Network MR Bi-Directional MR Non-Linear

Input Data Types: Ind/Ind Ind/SS SS/Ind SS/SSfamily

Exposure Trait Types: Quantitative Binary Time to event

Outcome Trait Types: Quantitative Binary Time to event

Assumptions and Sources of Bias

Source of Bias Addressed
Weak instruments ✗
Winner’s curse ✗
Sample overlap ✗
Uncorrelated horizontal pleiotropy ✓
Correlated horizontal pleiotropy ✓
Ancestry differences in samples ✗
Residual confounding in GWAS ✗
Cross-trait assortative mating ✗
Index-event/conditioning on heritable trait ✗

Description

This method clusters the per-SNP MR effect estimates to enable identification of heterogeneity and potentially pleiotropic groups of SNPs