Pleiotropy robust MVMR
Resources
Code (Language: R) Website Paper (Pub Date: 2021-08-02)
Other URLS: none
Method Contact: Andrew Grant ( none)
Entry Contact: Eleanor Sanderson ( eleanor.sanderson@bristol.ac.uk)
Context
Analysis Type: UVMR MVMR Network MR Bi-Directional MR Non-Linear
Input Data Types: Ind/Ind Ind/SS SS/Ind SS/SSfamily
Exposure Trait Types: Quantitative Binary Time to event
Outcome Trait Types: Quantitative Binary Time to event
Assumptions and Sources of Bias
| Source of Bias | Addressed |
|---|---|
| Weak instruments | ✗ |
| Winner’s curse | ✗ |
| Sample overlap | ✗ |
| Uncorrelated horizontal pleiotropy | ✓ |
| Correlated horizontal pleiotropy | ✓ |
| Ancestry differences in samples | ✗ |
| Residual confounding in GWAS | ✗ |
| Cross-trait assortative mating | ✗ |
| Index-event/conditioning on heritable trait | ✗ |
Description
This method extends MR-robust, MR-Median and MR-Lasso to multivariable MR. These methods provide MVMR estimation that is robust to pleiotropy in the genetic variants violating the third IV assumption under different assumptions about the nature of that pleiotropy.