Weak instrument robust MVMR
Resources
Code (Language: R) Website Paper (Pub Date: 2021-08-02)
Other URLS: none
Method Contact: Eleanor Sanderson ( eleanor.sanderson@bristol.ac.uk)
Entry Contact: Eleanor Sanderson ( eleanor.sanderson@bristol.ac.uk)
Context
Analysis Type: UVMR MVMR Network MR Bi-Directional MR Non-Linear
Input Data Types: Ind/Ind Ind/SS SS/Ind SS/SSfamily
Exposure Trait Types: Quantitative Binary Time to event
Outcome Trait Types: Quantitative Binary Time to event
Assumptions and Sources of Bias
| Source of Bias | Addressed |
|---|---|
| Weak instruments | ✓ |
| Winner’s curse | ✗ |
| Sample overlap | ✗ |
| Uncorrelated horizontal pleiotropy | ✗ |
| Correlated horizontal pleiotropy | ✗ |
| Ancestry differences in samples | ✗ |
| Residual confounding in GWAS | ✗ |
| Cross-trait assortative mating | ✗ |
| Index-event/conditioning on heritable trait | ✗ |
Description
A method for multivariable Mendelian randomization to test for weak instruments and estimate causal effects that are robust to weak instruments.